Vaccine-associated Enhanced Disease: Case Definition and Guidelines for Data Collection, Analysis, and Presentation of Immunization Safety Data
Source: Brighton Collaboration
This is a Brighton Collaboration case definition of the term “Vaccine-associated Enhanced Disease” (VAED) to be utilized in the evaluation of adverse events following immunization. The case definition was developed by a group of experts convened by the Coalition for Epidemic Preparedness Innovations (CEPI) as part of the Safety Platform for Emergency vACcines (SPEAC) project, in the context of active development of vaccines for COVID-19 and other emerging pathogens. The case definition format of the Brighton Collaboration was followed to develop a consensus case definition and defined levels of diagnostic certainty, after an exhaustive review of the literature and expert consultation.
The success of vaccines brings the responsibility to ensure that immunisations remain as safe as possible, particularly since they are given to healthy individuals. Vaccines are now distributed faster and to wider populations than ever before. Reliable safety information must be available rapidly on a similar scale so that vaccine recipients and decision makers can evaluate vaccine benefits and risks accurately. We are committed to address this need. We improve health through vaccine safety and rigorous science.
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